Question : Does sysprep completely clean old network, domain and user settings in XP ?

I am going to install a new machine (same HP corporate model D220)  based on a previous image, using sysprep.  Does sysprep completely clean old settings or are there other steps that are recommended prior to doing a sysprep.
After a sysprep, is the old domain information removed (I'd like to make sure I get as "clean" a machine as possible) ? I noted in the past that existing user local  ID's are kept. So that means I have to delete them prior to sysprep;ing. Any other things or way to clear old info?
 For example OUtlook Express was created anew, is that the same with outlook?

Answer : Does sysprep completely clean old network, domain and user settings in XP ?

Yes, Sysprep will do this for you, it will clear the SID, domain,etc...  I don't believe they clear the user profiles.  It is best to have a clean the system before you sysprep it so that you have a good baseline.