Why the mix of A/V products?
Verify that ESET has no issues with SBS 2008 on their support site and make sure their product is up to date.
Symantec has an MP4 version of their product to address SBS 2008 incompatibility issues among others.
Check the %windir%\MiniDump folder for any dumps. Are there any? If so, zip up the last two or three and rename the extension to .txt and post here. I can have a look at them for you.
Broadcom NIC drivers on Dell and others have been known to cause some funky behaviours in SBS 2008 in my experience. Make sure that only 1 NIC is enabled in the BIOS, and if there are two with one disabled in the OS, note the MAC address of the correct NIC BEFORE disabling it.
Philip