Theres really only a few simple ways around this.
1) Train the user to Book the Conference Room First.
Once accepted. Then go back into the Appointment, and then add the Attendees.
Update the meeting. Send Responses Only to Added or Removed Users.
2) Add all staff (Or Selected Staff Members) as delegates of this conference room.
Set their permissions to Reviewer Only
This will allow the staff member to check the conference room first, before making an appointment, to see if its already booked for that time or not.