I know what you are talking about, but I usually get it if I double click too fast/slow. Maybe your speeds are too high/low for the Double Click?, and if you dont click just right, Windows thinks it is a single click?
Go to the Control Panel>Mouse Properties>and play with the click speeds to see if that corrects the problem, or at least minimizes it a tad....
http://download.microsoft.com/download/f/c/a/fca6767b-9ed9-45a6-b352-839afb2a2679/TweakUiPowertoySetup.exehttp://download.microsoft.com/download/f/c/a/fca6767b-9ed9-45a6-b352-839afb2a2679/TweakUiPowertoySetup.exeHave you thought of changing your Click behaviour to Single Click to open? Might take some getting used to....
I also believe Tweak UI can control the clickspeed, but I dont think you are going to see that it fixes the problem, but thought I would offer it.
TweakUI
http://download.microsoft.com/download/f/c/a/fca6767b-9ed9-45a6-b352-839afb2a2679/TweakUiPowertoySetup.exeOther than that, you would have to modify the code for Explorer.wexe to stop the process... I dont think you will be able to do that even, without causing stability problems with Windows...