A direct fiber connection is best, but you haven't given us any information. That likely is not possible.
A common solution is to use a VPN between the two sites. This requires 2 VPN capable routers, and as mentioned both sites must use different network ID's (Subnets).
Keep in mind the VPN will likely run at 1/100th of the speed of your LAN. Will this meet the need of your backup solution?