Question : Exchange 2010 - Connection to Exchange is unavailable

A newly created Exchange 2010 environment is having issues getting local clients to connect.  I have tried autodiscover and manual.  OWA is working without issue, and so is remote Mac Mail.  

Configuration:
2 Mailbox servers in a DAG
1 CAS server
1 HUB server
2 DCs

When I try to manually set up the connection, it will resolve the name, but then say the connection to microsoft exchange is unavailable.  The same thing happens when I use autodiscover.  

Answer : Exchange 2010 - Connection to Exchange is unavailable

correct, it should work internally without using RPC -HTTPS
It should work straight out of the box, the only reason it wouldn't would be either a DNS issue or an Active Directory issue.

Can you post an IPCONFIG /ALL from your client and the exchange server.